23 results
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... such as • Statin-induced ... myopathy (SAMS) ... Atorvastatin Diagnosis ... #diagnosis #management
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
Myositis Necrotizing myopathy ... anti-synthetase syndrome ... /full triad at diagnosis ... and anti-HMGCR myopathy ... after 2 years of treatment
Generalized Weakness - Differential Diagnosis Framework
"l feel weak":
 • Infectious: Influenza, EBV, PNA, Bacteremia, Sepsis
 •
- Differential Diagnosis ... CV/Resp/Heme: CHF ... I am weak": • Myopathy ... Polyneuropathy, ALS ... #Differential #Diagnosis
Myositis Specific Antibodies (MSAs)

Dermatomyositis: MDA5, TIF1y, NXP2, Mi-2, SAE
Anti-Synthetase Syndrome: Jo-1, PL7, PL12, EJ, OJ
Immune Mediated
Anti-Synthetase Syndrome ... Mediated Necrotizing Myopathy ... MSAs #clinical #diagnosis ... #rheumatology #table
Cardiorenal Syndrome (CRS) Types
 • Type 1 - Acute CRS: Alteration of renal perfusion is the
Cardiorenal Syndrome ... Type 3 - Acute RCS ... Hypertension, CKD induced myopathy ... #Cardiorenal #Syndrome ... #CRS #Types #cardiology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Motor Nerves: ALS ... Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy ... #differential #diagnosis
Chest Pain - Differential Diagnosis Framework

Cardiovascular Causes of Chest Pain:
 • Myocardium:
	- Myocarditis
	- CAD/ACS
	- Valvulopathy
	- Myopericarditis
- Differential Diagnosis ... Myocarditis - CAD/ACS ... Costochondritis - Tietze syndrome ... • Alveoli: - CHF ... #Causes #Cardiology
Iron Deficiency in Heart Failure - Diagnosis and Treatment Algorithm
Diagnosis: Ferritin <100 ng/mL (absolute ID) OR
and Treatment Algorithm ... Guidelines: • ACC ... iron #deficiency #CHF ... management #algorithm #cardiology ... #treatment #guidelines
Beta Blockers - Pharmacology Comparison Table
Metoprolol:
 • Receptors: β1
 • Indications: Rate control of a-fib/a-flutter, Suppression
Suppression of PACs ... Acute coronary syndrome ... in pt w/o CAD/HF ... Pharmacology #Comparison #Table ... #Receptors #cardiology
ISCHEMIA Trial - Management Algorithm for patients with Stable Angina

Stress Test -> ? +moderate or severe
patients with Stable ... acute coronary syndrome ... (ACS) evaluation ... Angina #ChestPain #Diagnosis ... Management #Algorithm #Cardiology