329 results
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
• Acute stroke syndromes ... Paraneoplastic syndrome ... proximal weakness Myopathy ... mediated necrotizing myopathy ... Differential #Diagnosis #neurology
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Guillain-Barre syndrome ... Lambert Eaton Syndrome ... Mitochondrial myopathy ... differential #diagnosis #neurology
Myoedema in Hypothyroidism on Physical Exam

Hypothyroidism is a clinical syndrome resulting from the production, secretion or
is a clinical syndrome ... and scaly skin, myopathy ... Myopathy due to ... clinical #video #neurology
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
Lambert-Eaton Myasthenic Syndrome ... • Congenital Myopathy ... Peripheral #Weakness #Neurology
Ptosis - Differential Diagnosis Framework

Ptosis (Greek- to fall) Drooping of the upper eyelid that usually results
Horner’s syndrome ... Neurogenic Ptosis - Neurologic ... Mitochondrial myopathy ... gravis • Ocular myopathy ... #Ptosis #neurology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Differential Diagnosis Neurologic-Centered ... late-onset nemaline myopathy ... capillary leak syndrome ... • Schnitzler syndrome
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
Respiratory Distress Syndrome ... cardiac arrest Neurologic ... Cerebral edema, myopathy
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
capillary leak syndrome ... et diutinum Neurologic ... Hyperviscosity syndrome ... late-onset nemaline myopathy ... (Dermato-neuro syndrome
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Differential diagnosis of myopathy ... #Hypothyroid myopathy ... Corticosteroid-induced myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Idiopathic Inflammatory Myopathies ... Immune-Mediated Necrotizing Myopathy ... Antisynthetase Syndrome ... #Inflammatory #Myopathies ... #Idiopathic #Myopathy