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diagnosis hematology blood disease lupus product reactions sle syndrome treatment ana anca antibody antineutrophil antinuclear antinxp2 antinxp2dm behcet causes coagulation
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Antineutrophil cytoplasmic antibodies ... scleroderma) - Anti-Scl ... polyangiitis without renal ... Antineutrophil #antibodies ... #diagnosis #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
Renal involvement ... /min • <60 mL/ ... TerrierBen #Renal ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology #
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
concentration: > 750ng/mL ... probably < 1500ng/mL ... Special cases (e.g. renal ... Measurement #SLE #rheumatology ... levels #lupus #management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
disease (panuveitis, retinal ... involvement (uveitis or retinal ... Ocular: Giant retinal ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
pancreas, biliary, renal ... autoantibodies (antinuclear antibodies ... Disease #diagnosis #management ... workup #treatment #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Bleeding (64%) • Renal ... HIT: Heparin-PF4 antibodies ... causes #treatment #management ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... La, anti-Jo-1, SCL ... -70, RNP antibodies ... anticardiolipin antibodies
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Rh) & recipient antibodies ... , DIC, hypoTN, renal ... anti-platelet antibodies ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Rh) & recipient antibodies ... , DIC, hypoTN, renal ... anti-platelet antibodies ... Transfusions #diagnosis #management ... #hematology #reactions
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... examination Labs: • Antibodies ... • Antinuclear antibodies ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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