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diagnosis management hematology differential antibody blood disease lupus nuclear patterns product reactions sle testing treatment workup addisons adrenal algorithm anca
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... scleroderma) - Anti-Scl ... #Antinuclear #Antibody ... #antibodies #diagnosis ... #rheumatology #
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Corpuscular Volume (MCV ... B12 - Anti-IF Antibodies ... • Rule out B12 and ... #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
function test, ANA ... anti-phospholipid antibodies ... changes), high MCV ... patients if the cause ... #Workup #hematology
Multiple Myeloma and Monoclonal Gammopathies C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN R
dL the ULN R - Renal ... /dL or CC < 40 ml ... Causes of false- ... amyloidosis Other causes ... MGUS #diagnosis #hematology
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
and probably < ... suspected) • In case ... • Special cases ... (e.g. renal failure ... Measurement #SLE #rheumatology
IgG4-Related Disease Clinical history: Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor 4 phenotypes: •
aorta • Head and ... pancreas, biliary, renal ... autoantibodies (antinuclear ... antibodies, rheumatoid ... workup #treatment #rheumatology
Primary Adrenal Insufficiency Addison's Disease - Damage of the adrenal glands with lack of cortisol, androgens and
aldosterone Causes ... Lung cancer • Renal ... 21-Hydroxylase Antibodies ... 21-hydroxylase antibodies ... Administer 250 mcg
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
hypofunction • Antibodies ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Hypocomplementemia • Can cause ... Sjogrens #Syndrome #Rheumatology
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