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diagnosis differential patterns antibody management testing anca antineutrophil antinxp2 antinxp2dm associations autoantibodies causes cytoplasmic dermatology dermatomyositis diseases disorders erythematosus hematology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... Smith, Sm/RNP, Scl ... ARUPConsult @ARUPLabs #ANA ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... scleroderma (SSc) • Nucleolar ... @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... (ANA) ANA or Anti-NucIear ... @AnnKumfer #Antinuclear ... #Antibodies #ANA ... #patterns #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
ANA (Antinuclear ... in drug-induced SLE ... scleroderma) - Anti-Scl ... Jcortesizaguirr #ANA ... #rheumatology #
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Autoantibodies in Rheumatology ... • Lupus (SLE): ... ANA (anti-nuclear ... others (RNP, aPL antibodies ... Autoantibodies #Rheumatology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... Homogeneous pattern: • SLE ... pattern: • SjS, SLE ... #Antinuclear #Antibody ... differential #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
(e.g., SLE), anti-phospholipid ... antibodies, Quantitative ... changes), high MCV ... thrombocytopenia is unclear ... Causes #Workup #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... APLA/LAC: • Renal ... La, anti-Jo-1, SCL ... -70, RNP antibodies ... anticardiolipin antibodies
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... hypofunction • Antibodies ... ab • RF • Antinuclear ... antibodies ≥ 1: ... Sjogrens #Syndrome #Rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
• Antibodies targeting ... dorsal part of the MCP ... Papillary carcinoma • Clear ... cell renal carcinoma ... diagnosis #management #rheumatology
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