100 results
Infective Endocarditis: Modified Duke Criteria
Clinical Criteria: 
1. Two major criteria 
2. One major and three minor
One major and three ... #Diagnosis #InfectiousDiseases
Lone Star Tick Diseases

Human Monocytic Ehrlichiosis
Southern Tick Associated Rash Illness (STARI)
Heartland Virus

Dr. Ann Marie Kumfer @AnnKumfer

#LoneStar
Lone Star Tick Diseases ... #Differential #Diagnosis ... #InfectiousDiseases
Hypercalcemia of Malignancy - Pathophysiology
PTH-mediated
 • Parathyroid cancer
 • Ectopic production: Small cell lung cancer, ovarian
of Malignancy - Pathophysiology ... resorption in the bone ... resorption in the bone ... Hypercalcemia #Malignancy #Pathophysiology ... #Differential #Diagnosis
Osteoporosis: Pathogenesis and risk factors

 • Age > 30 (post-peak bone mass)
 • Post-menopausal women ->
30 (post-peak bone ... Decr estrogen • Bone ... #Osteoporosis #pathophysiology ... signs #symptoms #diagnosis
Pisa Syndrome (pleurothotonus) on Physical Exam
A tonic flexion of the trunk of the body to one
of the body to one ... degrees due to dystonia ... Pathophysiology:
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... collection with EDTA Pathophysiology ... Muscular/Rheum: - Hypotonia ... Difficulty walking Diagnosis ... Hyophosphatasia #hepatology #diagnosis
Gaucher Disease 

Pathophsiology
 • Lysosomal storage disorder
 • Deficiency of ß-glucocerebrosidase
• Accumulation of glucosylceramide in macrophages
Diagnosis
Gaucher Disease Pathophsiology ... in macrophages Diagnosis ... Osteonecrosis, bone ... Gauchers #Disease #Diagnosis
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
Leishmaniasis #LifeCycle #diagnosis ... #pathophysiology ... #infectiousdiseases
Pott's Disease in Tuberculosis - Diagnosis and Management Summary
Epidemiology:
 - Typically from TB endemic areas
 -
Tuberculosis - Diagnosis ... decreased reflexes Pathophysiology ... of bacilli to bone ... dissemination Diagnosis ... CXR should be done
Rheumatoid arthritis (RA): X-ray features
 • Soft tissue swelling (best seen by comparing left & right
the articular bone ... #RA #HandXray #Diagnosis ... Radiology #Clinical #Pathophysiology