12 results
Giant Cell (Temporal) Arteritis: Pathogenesis and investigations
Risk Factors:
 - Unclear environmental triggers (may be viral, not
Giant Cell (Temporal ... yrs old; F>M Signs ... Anemia - Giant cells ... Pathophysiology #Diagnosis #Signs ... #Symptoms #Vasculitis
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... or basket cells ... Contamination, colitis ... workup #oncology #hematology
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
B and CD-4+ T cells ... CRP Neuronal cell ... Prolonged PR Interval, Carditis ... pathophysiology #diagnosis #signs ... #symptoms #complications
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
polymorphisms alter cell-mediated ... various inflammatory cells ... histopathologic term ... Pathophysiology #Diagnosis #Signs ... #Symptoms
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
commonly hairy-cell ... vascular endothelial cells ... Pathophysiology #Diagnosis #Signs ... #Symptoms #Vasculitis
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
• Langerhan cells ... UV light Incr cell ... Livedo Reticularis, Vasculitis ... pathophysiology #diagnosis #signs ... #symptoms #complications
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... systemic sx + signs ... them, but urgent rheumatology ... GCA #Temporal #Signs ... #Symptoms #Diagnosis
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... CRP GCA (Giant Cell ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... meningitis), MCC CNS symptoms ... disease, ulcerative colitis ... diagnosis #management #signs ... #symptoms #rheumatology
Mastoiditis: Pathogenesis and clinical findings

Acute or Chronic Otitis Media -> 
Stage 1: Hyperemeia of the mastoid
the mastoid air cells ... ) Stage 4: Cell ... larger & irregular cavities ... pathophysiology #signs ... #symptoms #diagnosis