20 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential Diagnosis ... Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH ... #Differential #Diagnosis
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... structure of a normal ... destruction or hemolysis ... Pathophysiology #Honc ... HereditarySpherocytosis #NEJM
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
- Infection (EBV ... Thrombosis 5-10x normal ... muscle 2-5x normal ... - Hemolysis, NASH ... #differential #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... HBV, HCV, HEV, EBV ... - If both are normal ... Bilirubin: RBC (hemolysis ... #differential #diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... Diagnosis: • hemolytic ... • Compensated hemolysis ... - Mycoplasma, EBV ... Hemoglobinuria (PCH
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... upon damage • Normal ... : • Hemolytic ... anemia, PNH, immune ... #differential #diagnosis
Causes of Acute Pharyngitis
• 200 visits per year per 1000 people
   - i.e. 400
visits/year for a PCP ... - 11 million diagnoses ... (herpangina), EBV ... • Group A beta-hemolytic ... #differential #diagnosis
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential Diagnosis ... Bacterial • Viral (EBV ... Hepatic, Portal, ... Serum Sickness Hemolytic ... #Differential #Diagnosis
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... Normal range 11.5% ... acute blood loss, hemolysis ... under 2%, then BM ... Anemia #Algorithm #Diagnosis