13 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... Levels: > 50x normal ... - Infection (EBV ... Patterns #Liver #Injury ... #hepatology #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... , PSC, IgG4, HLH ... - If both are normal ... function may be abnormal ... diagnosis #algorithm #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... C, A, E, B, D, EBV ... , 1° PSC, Cystic ... Sophia_Hayes_MD #Liver #Injury ... Acute #algorithm #hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH ... Algorithm #Causes #Hematology
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
(>10^6 IU/mL), normal ... (<2000 IU/mL), normal ... (>10^6 IU/mL), normal ... with severe liver injury ... Indications #management #hepatology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Marrow (Toxic injury ... to BM) • Constitutional ... syndrome (MDS) (normal ... megakaryocytes and a normal ... Anemia #oncology #hematology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
bearing after injury ... HSV, Varicella, EBV ... injuries - Meniscal injury ... Effusions: - Hematologic ... - Synovium - Oral
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hematological: - HIT, PNH ... • Drugs: - Oral ... - COVID-19 - PNH ... Vasculitis • Injury ... pathophysiology #hematology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
pattern of liver injury ... reported (eg AIH-PBC ... upper limit of normal ... Diagnosis #Management #Hepatology