13 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH ... Algorithm #Causes #Hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH ... Liver Disease, PNH ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
- Infection (EBV ... Thrombosis 5-10x normal ... muscle 2-5x normal ... - Hemolysis, NASH ... Liver #Injury #hepatology
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... structure of a normal ... destruction or hemolysis ... Pathophysiology #Honc ... HereditarySpherocytosis #NEJM
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... - If both are normal ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... diagnosis #algorithm #hepatology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Donath-Landsteiner Antibodies[PCH ... Diagnosis: • hemolytic ... - Mycoplasma, EBV ... Hemoglobinuria (PCH ... #anemia #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Bacterial • Viral (EBV ... Hepatic, Portal, ... Serum Sickness Hemolytic ... Algorithm #Causes #Hematology
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Normal range 11.5% ... acute blood loss, hemolysis ... in bone marrow (BM ... under 2%, then BM ... Diagnosis #Workup #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... deficiencies - PNH ... Decreased Support Of Dermal ... Differential #Diagnosis #hematology ... #rheumatology #
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Cryoglobulinemic, Hypo/normo-complementemic ... WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology