10 results
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... and RES-mediated hemolysis ... Drug-induced AIHA - Abnormal ... Cold AIHA • PCH ... • PNH
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
HBV, HCV, HEV, EBV ... - If both are normal ... Gilbert's syndrome • Hemolysis ... Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... - Infection (EBV ... muscle 2-5x normal ... - Hemolysis, NASH ... #Patterns #Liver
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH ... Defects, Drugs, Liver ... Disease, PNH ... Blood Smear ↑ abnormal
Hemolysis in Hereditary Spherocytosis. Panel A shows the structure of a normal red cell and a
Hemolysis in Hereditary ... structure of a normal ... destruction or hemolysis ... Pathophysiology #Honc ... HereditarySpherocytosis #NEJM
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework

LDH is a cytoplasmic enzyme present in tissues throughout
RBCs, muscle, liver ... upon damage • Normal ... bloodstream Hemolysis ... : • Hemolytic ... anemia, PNH, immune
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... deficiency • Liver ... deficiencies - PNH ... Decreased Support Of Dermal
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Cryoglobulinemic, Hypo/normo-complementemic ... WAIHA • CAD • PCH ... Evans • ITP • Cl-NH ... • Coombs (-) hemolytic
Perirenal Extramedullary Hematopoiesis - Magnetic resonance imaging of the abdomen, performed without the administration of contrast
splenomegaly, a normal-appearing ... liver, ascites, ... Radiology #Pathology #Honc ... ExtramedullaryHematopoiesis #Microscopy #NEJM
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
acute HIV, HBV, EBV ... Sarcoidosis) • Liver ... lung cancers, HCC ... chain assay • An abnormal ... light chain • Normal