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Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... Injury • Pre-Renal ... : NSAIDS, CNI, ACEI ... therapy • Osmotic injury ... , Antibiotics, NSAIDs
Medications causing Acute Kidney Injury (AKI) Prerenal: • Dehydration: Diuretics • Altered intrarenal autoregulation: ACEIs / ARBs,
causing Acute Kidney ... Injury (AKI) Prerenal ... ACEIs / ARBs, NSAIDs ... #AKI #Acute #Kidney ... #Injury #Medications
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Prerenal: • Due to true volume loss or decreased
Acute Kidney Injury ... sepsis • Drugs: NSAIDs ... Cellular debris • Kidney ... LouLectures #Acute #Kidney ... #Injury #AKI #Differential
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
e.g. diuretics, NSAIDs ... No structural kidney ... injury: No proteinuria ... other cause of kidney ... other cause of kidney
NSAID vs ACEI/ARB effects on the Kidneys Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAID vs ACEI/ARB ... Remember that NSAIDs ... NSAIDs cause vasoconstriction ... function, NSAID ... /ambcarerx #NSAIDs
NSAID Pharmacology - Amy Chung, MD, MSc @AmyChung #NSAIDs #Pharmacology #COX #Cyclooxygenase
NSAID Pharmacology ... @AmyChung #NSAIDs
Acute Kidney Injury Framework - Differential Diagnosis Algorithm #AKI #Acute #Kidney #Injury #Differential #Diagnosis #Algorithm #causes
Acute Kidney Injury ... #AKI #Acute #Kidney ... #Injury #Differential
KDIGO Definition of Acute Kidney Injury (AKI) #Diagnosis #Nephrology #KDIGO #AKI #Acute #Kidney #Injury
Definition of Acute Kidney ... Injury (AKI) ... KDIGO #AKI #Acute #Kidney ... #Injury
NSAID Selectivity Spectrum COX-2 Selective NSAID - Celecoxib • Increased risk for CV events • Decreased risk
NSAID Selectivity ... COX-2 Selective NSAID ... Semiselective NSAIDs ... risk Nonselective NSAIDs ... side effects #NSAIDs
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 Prerenal Acute Kidney Injury - Diagnostic Schema Hypovolemia Hypervolemia Hypotension Vessels #Prerenal #Acute #Kidney #Injury #AKI #Diagnosis
Prerenal Acute Kidney ... Injury - Diagnostic ... Prerenal #Acute #Kidney ... #Injury #AKI #Diagnosis
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