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NSAID vs ACEI/ARB effects on the Kidneys

Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAID vs ACEI/ARB ... Remember that NSAIDs ... NSAIDs cause vasoconstriction ... kidney function, NSAID ... use shouldn't cause
NSAID Pharmacology

- Amy Chung, MD, MSc @AmyChung 

#NSAIDs #Pharmacology #COX #Cyclooxygenase
NSAID Pharmacology ... @AmyChung #NSAIDs
NSAID Selectivity Spectrum
COX-2 Selective NSAID - Celecoxib
 • Increased risk for CV events
 • Decreased risk
NSAID Selectivity ... COX-2 Selective NSAID ... Semiselective NSAIDs ... risk Nonselective NSAIDs ... side effects #NSAIDs
Renal Effect of NSAIDs Inhibition of Prostaglandin Synthesis

 - Renal disease, Cardiovascular disease -> Decreased renal
Renal Effect of NSAIDs ... Vasopressin NSAlDs ... #NSAIDs #Prostaglandins
Drugs Causing Acute Pancreatitis

Class Ia: The medications in which there was a rechallenge and other causes
rechallenge and other causes ... out other common causes ... Class II: Cases ... and atleast4 case ... #Pancreatitis #Causes
Causes of Nausea and Vomiting - Differential Diagnosis Framework

Chemoreceptor Trigger Zone/Area Postrema:
 • Drugs:
	- Chemo agents
	-
Causes of Nausea ... - Opioids - NSAIDS ... Malignancy #nausea ... differential #diagnosis #causes
Causes of Small Bowel Bleeding - Differential Diagnosis
Common Causes:
 • Under age 40 years: Inflammatory Bowel
Causes of Small ... Diagnosis Common Causes ... lesions, Neoplasia, NSAID ... ulcers Rare Causes ... Kaposi's sarcoma with AIDS
NSAIDs and GI versus CV risk

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#pharmacology #comparison #cardiology #gi #nsaids #pain #medications #management
NSAIDs and GI versus ... cardiology #gi #nsaids
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Nephrotoxic drugs (e.g NSAlDs ... PROBLEM ~80% of AKI cases ... are caused by prerenal ... CONSIDER INTRINSIC CAUSES ... for WBCs, RBCs, casts
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Heaves menses, NSAIDs ... differential #diagnosis #causes