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Antiarrhythmics Pharmacology Summary Cardiac Conduction Phases: Phase 0 - Ventricular Depolarization: • Na+ channels open leading to a
Depolarization: • Na ... leading to a rapid Na ... Repolarization: • Na ... MOA: Block fast Na ... categories based on Na
Volume Based Approach to Hyponatremia Hypovolemic, Serum uric acid >4 • Urine Na <20: Extra-renal losses •
acid >4 • Urine Na ... 20: Extra-renal losses ... • Urine Na >30 ... : Renal losses, ... acid >4 • Urine Na
Antiarrhythmics - Vaughan Williams Classification: CLASS 1 - Sodium Channel Blockers: • MOA: Block fast Na+ channels
Classification: CLASS ... MOA: Block fast Na ... categories based on Na ... duration: - CLASS ... receptors, and Ca & Na
Antiarrhythmics - Vaughan Williams Classification Class I (Ia, Ib, Ic) - Na+ Channel Blockade • Slows depolarization
Classification Class ... (Ia, Ib, Ic) - Na ... Widens QRS complex Class ... prolongs PR interval Class ... Classification #Classes
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
diuretics: • Inhibit Na ... diuretics: • Inhibit Na ... diuretics: • Inhibit Na ... diuretics: • Promote Na ... loop #thiazide #classes
Drugs Causing Acute Pancreatitis Class Ia: The medications in which there was a rechallenge and other causes
Pancreatitis Class ... Class lb: Atleast ... Class II: Cases ... Class Ill: 2 published ... Class IV: Weakest
Hypo-osmolar Hypotonic HypoNatremia Algorithm (Serum Na+ < 135 meq/L, serum Osm < 275 mosm/kg) Assess Volume Status,
Algorithm (Serum Na ... Status, Check Urine Na
Hyponatremia Differential Diagnosis Table • Step 1: Correct for hyperglycemia. Corrected Na = [(glucose - 100)/
Corrected Na = [ ... Urine Osm • Na ... of total body Na
Class I Antiarrhythmics and their Key Pharmacologic Properties Class IA = Quinidine, Procainamide, Disopyramide ("Quarter PounDer") Class IB
Class I Antiarrhythmics ... Properties Class ... Mayo, Pickle") Class ... Block fast Na ... QRS on EKG • Na
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Causes of Hypokalemia ... Stimulation of Na ... Diagnosis #Algorithm #causes
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