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diagnosis management sle differential erythematosus algorithm systemic table anemia clues cns cppd dermatology druginduced extravascular glomerulonephritis gout hemolysis hemolytic intravascular
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Disease, PRES Pathophysiology ... autoantibodies that will cause ... Cerebritis: Labs ... Cerebritis Induction ... CNS #neurology #rheumatology
Causes of Isolated Neutropenia - Differential Diagnosis Algorithm Congenital Medications • Anticonvulsants • Antibiotics • Antithyroid • Antihypertensive
Causes of Isolated ... Anticonvulsants • Antibiotics ... Bacteria • Gram Negative ... Destruction • Systemic Lupus ... #Hematology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Post-strep GN, Lupus ... Pauci-immune mediated (Negative ... diagnosis #algorithm #rheumatology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... , oral ulcers, Lupus ... Positive in 60-80% of cases ... pANCA anti-MPO - Negative ... Management #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
cases, drug-dependent ... Discontinuation of causal ... pANCA anti-MPO - Negative ... #sle #comparison ... #table #rheumatology
Top 10 situations when to think about lupus 1) Inflammatory joint pain (especially in the wrists and
to think about lupus ... pericarditis » is...lupus ... responsive to antibiotics ... Lupusreference #lupus ... erythematosus #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... Drugs (Beta lactam antibiotics ... Extravascular #Causes ... differential #diagnosis #hematology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
blood donor • Pathophysiology ... without other cause ... transfusion • Pathophysiology ... Transfusion #Reactions #hematology ... #diagnosis #comparison
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... affected areas and if negative ... syndrome with acne: antibiotics ... SAPHO #Syndrome #Rheumatology ... diagnosis #management #Dermatology
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
disease states Pathophysiology ... Needle-shaped, negatively ... #CPPD #Gout #Comparison ... #rheumatology #
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