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pharmacology review diagnosis cardiology differential endocarditis amikacin aminoglycosides bactrim chloramphenicol dalbavancin dalvance daptomycin gentamicin management septra streptomycin sulfonamides tmpsmx tobramycin
Daptomycin - Antibiotics Class Overview Mechanism: Lipopeptide antibiotic – forms transmembrane channels and depolarizes cells.
Class Overview ... Spectrum: only covers ... No gram negative ... more for MRSA bacteremia ... #Review #Overview
Aminoglycosides - Antibiotics Class Overview Gentamicin, Tobramycin, Amikacin, Streptomycin -30S inhibitor (all IV) Spectrum: Extremely efficacious vs.
Aminoglycosides - Antibiotics ... Class Overview ... inhibitor (all IV) Spectrum ... suspected (pneumonia, bacteremia ... #Review #Overview
Vancomycin and Dalbavancin (lipoglycopeptide antibiotics) - Antibiotics Class Overview Mechanism: Glycopeptide - inhibits cell wall synthesis
Class Overview ... Spectrum: gram positive ... No gram negative ... organisms, including bacteremia ... #Review #Overview
Causes of Culture Negative Abscess - Differential Diagnosis Framework Consider prior antibiotics as a cause of a
Causes of Culture ... Negative Abscess ... Consider prior antibiotics ... #Negative #Abscess ... Differential #Diagnosis #InfectiousDiseases
Sulfonamides - Antibiotics Class Overview BACTRIM/SEPTRA (TMP/SMX) - inhibit sequential steps in Folate synthesis --> bacteriostatic Spectrum: Wide
Sulfonamides - Antibiotics ... Class Overview ... bacteriostatic Spectrum ... : Wide spectrum ... and most Gram negatives
Endocarditis - Overview and Differential Diagnosis Framework Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV
Endocarditis - Overview ... Negative: • Bartonella ... Treatment • IV antibiotics ... • Persistent bacteremia ... Diagnosis #cardiology #infectiousdiseases
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
positive in 90% of IE cases ... Culture (+): ... • Coagulase-negative ... • IV Antibiotics ... • Persistent bacteremia
Chloramphenicol - Antibiotics Class Overview – 50S ribosomal inhibitor. IV or PO (but PO form
Chloramphenicol - Antibiotics ... Class Overview ... Spectrum: Broad ... spectrum vs Gram ... E.faecium/VRE); Gram negatives
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