9 results
Daptomycin  - Antibiotics Class Overview

Mechanism: Lipopeptide antibiotic – forms transmembrane channels and depolarizes cells.
Daptomycin - Antibiotics ... Class Overview ... No gram negative ... MRSA bacteremia/endocarditis ... #Review #Overview
SPICE (SPACE) Organisms
 - Colloquial acronym for gram-negative bacteria that have inducible, chromosomal beta-lactamase genes known
acronym for gram-negative ... genes known as AmpC ... to beta-lactam antibiotics ... organisms in this class ... #Diagnosis #Microbiology
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Native and ... for TPN) and antibiotic ... #Sources #Causes ... Bacteria #Etiology #Differential ... #Microbiology #
Aminoglycosides  - Antibiotics Class Overview

Gentamicin, Tobramycin, Amikacin, Streptomycin -30S inhibitor (all IV)
Spectrum: Extremely efficacious vs.
Aminoglycosides - Antibiotics ... Class Overview ... . aerobic Gram negatives ... effect (mainly in endocarditis ... #Review #Overview
SPICE (SPACE) Organisms

Gram-negative bacteria that have inducible, chromosomal beta-lactamase genes known as AmpC - Resistance may
Organisms Gram-negative ... genes known as AmpC ... organisms in this class ... #Diagnosis #Microbiology ... #Resistance #Antibiotics
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... infective endocarditis ... #differential # ... #Endocarditis # ... InfectiousDiseases #Microbiology
General Bacterial Antibiogram - Antibiotics and Spectrum of Coverage
Make sure you consult your local antibiogram!
VRE -
Antibiogram - Antibiotics ... POSITIVES - GRAM NEGATIVES ... ampicillin, amox-clav/amp-sulbactam ... #Classes #Bacterial ... #Pharmacology #Microbiology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... positive in 90% of IE cases ... • Coagulase-negative ... Marantic (NTBE) Differential ... • IV Antibiotics
Endocarditis - Overview and Differential Diagnosis Framework

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV
Endocarditis - Overview ... and Differential ... Hypercoagulable (APLAS) Microbiology ... Treatment • IV antibiotics ... #Differential #