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diagnosis differential infectiousdiseases management causes algorithm cardiology diarrhea infections workup aspergillus associated bcnie beta betad betadglucan biomarkers blood capd checklist
Transplant Infections Timeline Pre-transplant: • Common bacteria (endogenous): Staphylococci (skin), Gram-negative bacilli (gut) • Viruses: HSV (reactivation) Engraftment:
Transplant Infections ... Timeline Pre-transplant ... : • Common bacteria ... Staphylococci (skin), Gram-negative ... Staphylococci (skin), Gram-negative
Important Fungal Stains Mycology Lab: • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
Important Fungal ... and chitin in fungal ... • India ink - "Negative ... #microbiology #microscopy ... #fungus #comparison
Hematuria in Post-Renal Transplant Patient Prevalence up to 12% in the postrenal transplant patient • Bacterial: Escherichia
in Post-Renal Transplant ... the postrenal transplant ... patient • Bacterial ... Simple Virus • Fungal ... cell carcinoma (native
Diarrhea Workup and Management Algorithm in Transplant Patients First Tier Microbiologic-Testing: 1. C. difficile PCR (Stool) 2. CMV qPCR
Management Algorithm in Transplant ... Patients First Tier Microbiologic-Testing ... Bacterial culture ... Breath test for bacterial ... above testing negative
Causes of blood culture negative infective endocarditis Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
blood culture negative ... Tropheryma whipplei, Fungi ... under BCNIE, these bacteria ... causes #culture #negative ... InfectiousDiseases #Microbiology
CAPD-associated peritonitis (Continuous Ambulatory Peritoneal Dialysis) - 5 Things To Know Diagnosis (Two of the following): (1) Clinical
Microbiology: • ... • 15-35% Gram negative ... peritonitis • Fungal ... prior abx use, fungal ... Washington University ID
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
Fungal Biomarkers ... Coccidioides - Negative ... Cryptococcus - Negative ... setting of GVHD) ID ... Galactomannan #diagnosis #comparison
Timeline of infections after solid organ transplantation can roughly be broken up into three time periods:
>6-12 mo from transplant ... febrilepodcast.com] #ID ... Ddx #Diagnosis #Transplant ... #TxID #SOT #Comparison ... #Microbiology
(1,3)-β-d-glucan Abundant cell wall polysaccharide, found in most fungi, except cryptococci, zygomycetes (mucor, rhizophus) and blastomyces. Sensitivity 64%-93%;
found in most fungi ... 87%-100% False Negatives ... blood • Certain fungus ... Positives: • Bacteremia ... diagnosis #laboratory #microbiology
Solid Organ Transplant - Diarrhea - Diagnostic and Workup Algorithm 1st Tier Microbiologic Testing: CDiff (stool), CMV
Solid Organ Transplant ... Algorithm 1st Tier Microbiologic ... pathogens 2nd Tier Microbiologic ... overgrowth If above negative ... malabsorption #Diarrhea #Transplant
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