54 results
Causes of blood culture negative infective endocarditis

Bartonella spp, Brucella spp, Coxiella burnetii, Chlamydia spp, Tropheryma whipplei,
culture negative ... #differential # ... #culture #negative ... InfectiousDiseases #Microbiology ... #CNIE #BCNIE #cardiology
Endocarditis Algorithm - Infective vs Noninfective Causes
Noninfective:
 • Malignancy
 • Autoimmune disease
 • Systemic infection
Native Valve
vs Noninfective Causes ... • HACEK • Culture-negative ... epidermidis • Gram-negative ... #Noninfective #Causes ... #Differential #
Blood culture contaminants
Grouped by gram negative vs gram positive vs other as well as never/maybe/probably
Some additional
Blood culture contaminants ... Grouped by gram negative ... #Infections #Microbiology ... #Micro #Differential
Epidemiological Clues That May be Helpful in Defining the Etiological Diagnosis of Culture-Negative Endocarditis

#Endocarditis #Bacteria #Differential
Epidemiological Clues ... Etiological Diagnosis of Culture-Negative ... Endocarditis #Bacteria #Differential ... Microorganisms #Clues
Streptocccus Pneumoniae
Microbiology: Gram Positive, Alpha-hemolytic, Catalase Negative
Epidemiology - 10% adult carriers:
 • Most common cause of:
Alpha-hemolytic, Catalase Negative ... • Most common cause ... media • Important cause ... sinus • Sputum culture ... Specificity of 97%) Treatment
Causes of Culture Negative Abscess - Differential Diagnosis Framework
Consider prior antibiotics as a cause of a
Causes of Culture ... - Differential ... antibiotics as a cause ... of a negative culture ... #Differential #
Psittacosis 
Pathogen: Chlamydia psittaci - obligate intracellular gram negative
Transmission:
 • Birds are the primary reservoir
 •
intracellular gram negative ... test • PCR • Culture ... danger of aerosol) Treatment ... first line of treatment ... Chlamydia #psittaci #microbiology
Infective endocarditis - etiology and sources of infection. 
 • Native and prosthetic 
valve endocarditis
 •
Native and ... Endocarditis #Sources #Causes ... Bacteria #Etiology #Differential ... #Microbiology #
Blood Culture-Negative Infective Endocarditis (BCNIE)
Definition: No etiology found after 3 separate blood cultures remain negative for
Blood Culture-Negative ... remain negative ... but important causes ... #BloodCulture #Negative ... Endocarditis #diagnosis #differential
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS) Microbiology ... • Coagulase-negative ... Marantic (NTBE) Differential ... Treat underlying cause ... diagnosis #management #cardiology