32 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... Erythematosus #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... Diagnosis and Management ... Positive in 60-80% of cases ... pANCA anti-MPO - Negative ... #Summary #rheumatology
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... Associated with skin ... block • Sjogren syndrome ... #Systemic #Lupus ... #management
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... pANCA anti-MPO - Negative ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
) is a skin condition ... Causes: - Idiopathic ... , breast CA - Hematologic ... - Lupus - Leukemia ... #diagnosis #dermatology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
Irreversible-biopsy required • Lupus ... • Loose anagen syndrome ... - Secondary to Skin ... • Discoid lupus ... Diagnosis #Algorithm #causes
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rule out other causes ... affected areas and if negative ... #Rheumatology # ... diagnosis #management ... #Dermatology
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... nodes: 13-15%, skin ... (16-32%): lupus ... anterior/posterior MSK ... Sarcoidosis #Diagnosis #Management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... - Purpura - Skin ... Cryoglobulins Cause ... reticularis & skin ... (e.g. systemic lupus
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
levels >1g/L • Negative ... cryoglobulins • Negative ... causes of secondary ... Antiphospholipid syndrome ... #hematology