9 results
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... modify immune function ... distal component of Nephron ... absorption in distal nephron ... #pathophysiology
Isocoria - Pupillary Defects - Differential Diagnosis Algorithm
Relative Afferent Pupil Defect
 • Optic Neuritis
 • Ischemic
Differential Diagnosis Algorithm ... dissociation) • Pharmacologic ... Neuromuscular Junction ... • Botulism Pharmacologic ... Differential #Diagnosis #Algorithm
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
reabsorption in the nephron ... Side effects include ... have good kidney function ... SGLT2 #Inhibitors #Pharmacology ... #Medications #DM2
Major Segments of the Nephron and their Functions 
 - Glomerulus - Formation of glomerular filtrate
Segments of the Nephron ... and their Functions ... #Segments #Function ... #Pathophysiology ... Tubules #Table #Pharmacology
Anisocoria - Pupillary Defects - Differential Diagnosis Algorithm

Physiological - Simple Anisocoria ( <O.5mm)
 - Anisocoria equal
Anisocoria - Pupillary Defects ... Differential Diagnosis Algorithm ... Neuromuscular Junction ... pilocarpine • Pharmacologic ... Pupillary #Pupils #Defects
Major Physiological Effects of Angiotensin II

Altered Peripheral Resistance
I. Direct vasoconstriction
II. Enhancement of peripheral noradrenergic
neurotransmission:
  A.
Physiological Effects ... Altered Renal Function ... excretion in distal nephron ... Nonhemodynamically mediated effects ... AngiotensinII #Pathophysiology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
titrate up to effects ... check the kidney function ... only few side effects ... Renal #Dosing #Pharmacology ... Management #Diabetes #DM2
Allopurinol Pharmacology Summary

Xanthine oxidase inhibitor blocking the formation of new uric acid
Initiate 1-2 days prior to
Allopurinol Pharmacology ... Dosing: 100 mg/m2 ... 10mL/min Side effects ... #Allopurinol #Pharmacology ... #pathophysiology
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity
Anthracyclines cause cardiomyopathy:
 ✖ Reduction in left ventricular ejection fraction
ventricular ejection fraction ... doxorubicin 150 mg/m2 ... , 350 mg/m2, and ... monitoring to detect ... cardiology #oncology #pharmacology