15 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
action on the nephron ... Metolazone) 5) Potassium-sparing ... triamterene) #nephron ... #diuretics #pharmacology ... #nephrology #medications
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Drug Induced Kidney ... Disease: Drug induced ... tubular injury: Antibiotics ... #KidneyInjury #differential ... #Medications
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Chlorthalidone POTASSIUM-SPARING ... #Diuretics #Medications ... #Pharmacology # ... summary #table # ... nephrology
Mechanisms of Drug-Induced Hyperkalemia 
 • Direct renin inhibitor (Aliskiren)
 • Renin release inhibition (NSAIDs, Beta-Blockers)
Mechanisms of Drug-Induced ... #hyperkalemia #differential ... pathophysiology #pharmacology ... #potassium #medications
Drug-Induced Seizures - OTIS-CAMPBELL

O - Organophosphate, oral hypoglycemics, opioid
T - TCA, theophylline
I - Isoniazid, Insulin
S -
Drug-Induced Seizures ... anticholinergics, amantadine, antibiotics ... #Seizures #Medication ... #Causes #Differential ... #Pharmacology #
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Hypothyroidism • Medication-induced ... : ART, Antibiotics ... Peripheral #Neuropathy #differential ... diagnosis #causes #neurology
Common Medications Known to Prolong QTc
Antiarrhythmics - Amiodarone, sotalol, flecainide, quinidine, dronedarone, dofetilide
Vasopressors/inotropes - Epinephrine, norepinephrine,
Common Medications ... , venlafaxine Antibiotics ... #Causes #differential ... #diagnosis #pharmacology ... #table
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • Recent IV potassium ... Beta blockers • Antibiotics ... Medications 2. ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
Hyperkalemia - Differential ... • Recent IV potassium ... Beta blockers • Antibiotics ... Medications 2. ... #high #nephrology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Generalized distal nephron ... Drug-induced hyperkalemia ... Potassium-sparing ... Metabolic #Acidosis #differential ... diagnosis #causes #nephrology