178 results
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... salivary ducts Clinical ... • Interstitial nephritis ... Adenocarcinoma Treatment ... #Rheumatology #
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... 40, F:M 9:1 • Clinical ... ulcers, Lupus nephritis ... life-threatening • Treatment ... Management #Summary #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Differential Diagnosis ... Non-autoimmune rheumatologic ... Clinical Features ... #Rheumatology
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Clinical Manifestations ... Erythematosus (SLE ... Erythematosus #SLE ... Signs #Symptoms #Rheumatology ... #Diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Rebound effect from treatment ... disease, Kawasaki, Nephrotic ... syndrome, POEMS ... #Differential #Diagnosis
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
block • Sjogren syndrome ... polymyositis overlap syndrome ... severe disease Treatment ... #Summary #diagnosis ... #rheumatology #
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
SHARP - Lupus Diagnosis ... Renal Disease (Nephritis ... #IMDAMNSHARP #sle ... erythematosus #rheumatology ... #diagnosis #mnemonic
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Clinically ... disorders • Diagnosis ... and Treatment Algorithm ... #HES #Hematology ... #eosinophils #diagnosis
Staphylococcus-associated GlomeruloNephritis - Diagnosis and Management Summary
CLINICAL
 • Nephritic syndrome (Casts)
 • Marked proteinuria (may be
GlomeruloNephritis - Diagnosis ... Management Summary CLINICAL ... • Nephritic syndrome ... proteinuria (may be nephrotic ... deposits common TREATMENT
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... Associations #diseases #diagnosis ... #table #rheumatology