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differential nephrology causes algorithm management hyponatremia treatment neurology table signs symptoms pediatrics peds psychiatry comparison edema low ncpe noncardiogenic pharmacology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... thiazide-sensitive sodium-chloride ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypernatremia - Differential Diagnosis Workup Algorithm 1) Check Urine Osmolality: > 600 mOsm/kg - Implies extrarenal mechanism
Differential Diagnosis ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... #Differential #Diagnosis ... Algorithm #nephrology #sodium
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
ascending limb Gitelman ... cell epithelial sodium ... of epithelial sodium ... -2 deficiency Nephrogenic ... Kidney #Nephrology #Diagnosis
Causes of Hypernatremia - Differential Diagnosis Inadequate water intake: • Lack of access to water Extrarenal hypotonic fluid
Causes of Hypernatremia ... - Differential Diagnosis ... insipidus • Nephrogenic ... #Differential #Diagnosis ... Causes #nephrology #sodium
Hypernatremia Diagnosis and Workup Step 1 . Repeat the sodium concentration. Step 2. Check plasma osmolality. NORMAL PLASMA
Hypernatremia Diagnosis ... Repeat the sodium ... mmol/L - true hyponatremia ... • nephrotic syndrome ... #Diagnosis #Workup
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... thiazide-sensitive sodium ... tachycardia • Seizures ... #Syndrome #diagnosis ... nephrology #management #pathophysiology
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... Neurological event 2) Sodium ... SaltWasting #SIADH #Pathophysiology ... #diagnosis #nephrology ... #hyponatremia #
Etiologies of Hypernatremia - Differential Diagnosis GI losses / Insensible losses Sodium Overload Transcellular Movement of Water Central Diabetes Insipidus
Etiologies of Hypernatremia ... - Differential Diagnosis ... Insensible losses Sodium ... congenital disorders Nephrogenic ... #Differential #Diagnosis
Modified Hyponatremia Algorithm Hypertonic Hyponatremia: Hyperglycemia, Mannitol, Urologic irrigants Hypotonic Hyponatremia: • ADH ON (UOsm > 100):
Modified Hyponatremia ... Algorithm Hypertonic Hyponatremia ... Cirrhosis, Nephrotic syndrome ... #Algorithm #diagnosis ... #sodium #nephrology
Hypernatremia - Differential Diagnosis and Treatment Hypernatremia is almost always due to unreplaced water loss (free water
Differential Diagnosis ... Diagnosis is primarily ... Diabetes Insipidus: neurogenic ... , nephrogenic 4 ... management #nephrology #sodium
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