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Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... (AKI) - Differential ... Congestion • Medications ... External obstruction, Neurogenic ... Diagnosis #nephrology
Hypernatremia - Differential Diagnosis and Treatment
Hypernatremia is almost always due to unreplaced water loss (free water
Differential Diagnosis ... The differential ... urine osm (in DI; high ... , Dehydration: neurologic ... Diabetes Insipidus: neurogenic
Acute Kidney Injury (AKI) - Differential Diagnosis Framework
Pre-Renal:
 • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Acute Kidney Injury ... (AKI) - Differential ... Nephrolithiasis) • Neurogenic ... #Kidney #Injury ... Diagnosis #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... - Differential ... insipidus • Nephrogenic ... Diagnosis #Causes #nephrology ... #sodium #high
Acute Kidney Injury - Classification
Prerenal:
 • Dehydration
 • Heart failure (a.k.a. cardiorenal syndrome)
 • Liver failure
Acute Kidney Injury ... obstruction) • Neurogenic ... tract infection • Medications ... #Kidney #Injury ... Classification #diagnosis #nephrology
Atlas of Urine Microscopy Findings
 • Epithelial cells - Normal
 • Renal tubular cells - Acute
tubular cells - Acute ... tubular injury ... - Up to 3 per high-power ... horsfall protein indicating ... acute tubular injury
Acute Kidney Injury (AKI) - Management Principles
Prerenal - Correct hemodynamic derangements:
 • If low preload →
Acute Kidney Injury ... IV Fluids • If high ... → No specific treatment ... ureteral stent(s) • Neurogenic ... #Kidney #Injury
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Lactate > 1.5 High ... Failure, Toxins/Medications ... , Spinal Cord Injury ... Low CO / High
Hepatitis B - Treatment Indications
Treatment not indicated:
 • Immune tolerant state - HBe-Ag detectable, high HBV
Indications Treatment ... HBe-Ag detectable, high ... HBe-Ag detectable, high ... with severe liver injury ... > 3 mg/dL) or acute
Acute Kidney Injury (AKI) in Patients with Cancer 

Cancer Related 
• Hypercalcemia 
• Intravenous contrast 
•
Acute Kidney Injury ... malignancies Treatment ... cyclophosphamide) #Acute ... Cancer #Oncology #Differential ... Classification #Nephrology