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diagnosis differential liver management injury hematology thrombocytosis aclf aih alcoholic autoimmune causes chemistry cirrhosis drug druginduced failure idiosyncratic induced interpretation
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... underlying liver disease ... Liver Injury (DILI ... #gastroenterology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... Alcohol-related liver disease ... dechallenge • Acute ... #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
presentation • Chronic ... symptoms of liver disease ... Diagnosis #Management #gastroenterology ... #algorithm #gastroenterology ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... differential #diagnosis #algorithm ... #hepatology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Differential Diagnosis Algorithm ... Infectious: • Acute ... disorders • Celiac disease ... effect following treatment ... #Causes #Hematology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
of cholestatic disease ... Alcoholic liver disease ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... • Infections: Chronic ... Differential #Diagnosis #Algorithm
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... - Concomitant diseases ... HCV, DILI, HCC, ... #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
from subclinical disease ... to acute liver ... - Symptoms of chronic ... regarding need for treatment ... Diagnosis #Management #Hepatology
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