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hematology coagulation differential causes abnormal disseminated intravascular laboratory prolonged pt treatment algorithm apml bleeding bruising differentiation hemophilia hemostasis isth microangiopathy
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
an inhibitor of normal ... PT and/or aPTT) ... Mixing #Study #diagnosis ... #hematology #pathophysiology ... #hematology #laboratory
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm Suspected TMA: Unexplained thrombocytopenia + MAHA
- Differential Diagnosis ... and Management ... hemosiderin • PT/aPTT ... normal • DAT ... #hematology
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC) Platelet count: • Expected: Low (or normal) • Elevation
Intravascular Coagulation (DIC ... aggregation PT, aPTT ... small vessels #DIC ... ISTH #Scoring #diagnosis ... #hematology #laboratory
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... intravascular coagulation (DIC ... Jcortesizaguirr #Abnormal ... #Causes #diagnosis ... #differential #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... may be normal in ... antigen (vWF:Ag) are normal ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
- Differential Diagnosis ... PT/NORMAL PTT: ... PT/ABNORMAL PTT ... PT/NORMAL PTT: ... #Hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
ATRA treatment Pathophysiology ... opacities • Diagnosis ... • Differential Diagnosis ... 500 mg QD until normal ... #management #hematology
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