59 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... • Muscular: normal ... CK, normal biopsy ... diagnosis #management #treatment ... #rheumatology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
Von Willebrand Disease ... PT/INR • Normal ... factor VIII) Treatment ... VonWillebrand #Disease ... #Diagnosis #Hematology
Causes of Polycythemia (Erythrocytosis) - Differential Diagnosis Algorithm
Relative - Normal RBC Mass / Decreased Plasma Volume
Algorithm Relative - Normal ... Positive - Low/Normal ... Abdominal Ultrasound ... Cyanotic Heart Disease ... Algorithm #Causes #Hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
or priapism • Lab ... values: WBC >100k ... , + lab signs of ... values: Elevated ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
sedimentation rate + Normal ... Non-autoimmune rheumatologic ... Cytopenias • Cardiac valve ... flares • CRP normal ... Erythematosus #Diagnosis #Rheumatology
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines
 • Severe Disease → Remission
Guidelines • Severe Disease ... Therapy; high-dose oral ... • Non-Severe Disease ... Vasculitis #Management #Treatment ... Guidelines #algorithm #rheumatology
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
screening for disease ... with established disease ... study (aPTT may be normal ... antigen (vWF:Ag) are normal ... #hematology
Krabbe Disease 

Check out this interesting case of Krabbe disease, a rare genetic leukodystrophy. Diagnosis was
Krabbe Disease ... case of Krabbe disease ... guide confirmatory lab ... testing and expedite treatment ... • Symmetric abnormal
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
HELLP - Grafts, Valves ... , Drugs, Liver Disease ... Electrolytes: Wilson's disease ... Blood Smear ↑ abnormal ... Differential #Diagnosis #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
ristocetin • Normal ... cytometry— GP lb ... defects of GP lb ... Von Willebrand Disease ... Platelet #disorders #hematology