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management rheumatology coagulation differential abnormal prolonged lupus pt syndrome table bleeding bruising classification cryofibrinogenemia deficiencies deficiency dic disseminated druginduced encephalopathy
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
to Evaluate an Abnormal ... K Antagonists, Heparin ... to identify the cause ... ISNeducation #Abnormal ... #diagnosis #hematology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Summary of Coagulation ... Medications - Heparin ... RA, SLE), Post-partum ... #table #comparison ... #diagnosis #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... (e.g. heparin contamination ... amyloidosis #Abnormal ... #Causes #diagnosis ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
INR < 2.3 - APTT ... < 1.5 x normal ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... unfractionated heparin ... e.g. heparin ... #Causes #diagnosis ... #differential #hematology
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
) - Diagnosis and ... Management Summary ... - CRP: Usually normal ... life-threatening • Treatment ... #rheumatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... may be normal in ... mild cases) • ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... Splenomegaly - CTD (SLE ... Associated - SLE ... #hematology #rheumatology ... #nonpalpable #dermatology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
and Management Summary ... marrow) -dys- (abnormal ... old, ~10,000 new cases ... #Management #treatment ... #hematology #oncology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... life-threatening • Treatment ... #comparison #table ... #rheumatology # ... diagnosis #management
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