45 results
Coagulation Cascade and Anticoagulant Sites of Action

- Amy Chung, MD, MSc https://twitter.com/AmyChung

#AntiCoagulation #Cascade #Anticoagulants #Medications #Pharmacology
Coagulation Cascade ... #Pharmacology #Pathophysiology ... Mechanisms #DOAC #Hematology
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Investigation of Abnormal ... Coagulation Tests ... #Algorithm #Coagulation ... #Abnormal #APTT ... #Laboratory #Hematology
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
numerals refer to coagulation ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
Prolonged PT (INR), Normal ... Prolonged PTT, Normal ... Prolonged PTT, Normal ... Algorithm #Causes #Hematology ... #coagulation #disorders
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
an inhibitor of normal ... to have 50% of normal ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
ISTH Scoring System for Disseminated Intravascular Coagulation (DIC)
Platelet count:
 • Expected: Low (or normal)
 • Elevation
Intravascular Coagulation ... Expected: Low (or normal ... consumption of coagulation ... Intravascular #Coagulation ... Scoring #diagnosis #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Destruction • Abnormal ... • Vasculitis Coagulation ... deficiencies Coagulation ... Intravascular Coagulation ... Algorithm #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... Decreased Support Of Dermal ... Differential #Diagnosis #hematology ... #nonpalpable #dermatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Intravascular Coagulation ... protein C and S Pathophysiology ... Thrombocytopenia - Normal ... - APTT < 1.5 x normal ... treatment #management #hematology
Sclerodactyly: Diffuse thickening of the skin on the hands, in this case due to Scleroderma. 
Note
Note loss of normal ... Images #Clinical #Photo ... #Dermatology #Skin