15 results
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
Rouleaux formation ... #Rouleaux #formation ... IgM #gammopathy #MGUS ... #Clinical #Pathology ... #Hematology #Smear
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
significance (MGUS ... , low-risk MGUS ... protein <1.5 gm/dL, normal ... whom there are no clinical ... diagnosis #management #hematology
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... Monoclonal #Gammopathy #Clinical ... Differential #Diagnosis #hematology ... #oncology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
extensive rouleaux formation ... leukemia #rouleaux #formation ... #Clinical #Smear ... #Hematology #Pathology
Autoagglutination should also be distinguished from “Rouleaux formation” wherein normal blood tends to form stacks on
from “Rouleaux formation ... ” wherein normal ... dilution with normal ... #Clinical #Pathology ... #Hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Summary Framework Hematologic ... sub-types based on the hematologic ... : • Abnormal FLC ... #Significance #hematology ... #diagnosis #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• MM • WM • MGUS ... • MGCSMGRS ... Cryoglobulinemic, Hypo/normo-complementemic ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Autoimmune diseases • Clinical ... also arise in normal ... Lymphomas • Other hematologic ... NonHodgkins #comparison #oncology ... #differential #hematology
Indications for Serum Protein Electrophoresis (SPEP)
 • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
fatigue, bone pain, abnormal ... ) • Rouleaux formations ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... significant fibrin clot formation ... Thrombocytopenia - Normal ... - APTT < 1.5 x normal ... treatment #management #hematology