65 results
RHABDOMYOLYSIS
•	Characterized by skeletal muscle breakdown & necrosis. 
•	Elevated Creatine kinase (CK) hallmark of rhabdomyolysis. 
•	Defined based
Creatine kinase (CK ... Defined based on CK ... • Half-life of CK ... peaks in 3 days, & normalizes ... and cefdinir #CK
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations

 • Immune Complex Deposition
    - Arthralgia, Arthritis
Weakness, Normal CK ... Weakness, Incr CK ... therapy), Normal CK ... Complications #pathophysiology
Creatine kinase (CK) is an intracellular enzyme present in skeletal muscle, myocardium & brain; smaller amounts
Creatine kinase (CK ... CK may increase ... creatine kinase (CK ... CK functions as ... first 3 days, and normalizes
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Clotting test normalizes ... test does not normalize ... diagnosis #hematology #pathophysiology
Autoimmune Gastritis - Pathophysiology

Anti-ParietaI Cell, CD4+ T Cells, Autoantibodies -> x Parietal Cells, x HCL, x
Autoimmune Gastritis - Pathophysiology ... Anti-ParietaI Cell, CD4 ... Autoimmune #Gastritis #Pathophysiology
Dermatomyositis (DM) and Polymyositis (PM): Pathogenesis and clinical findings
Elevated Antinuclear Antibodies: Anti-Jo-1, Anti-OJ, Anti-Mi2, Anti-SRP, Anti-EJ,
Creatinine kinase (CK ... regeneration, diffuse CD8 ... PM #Diagnosis #Pathophysiology
Therefore, studies obtained at the initial presentation in the emergency department should evaluate for fibrinolysis with
international normalized ... complete blood count (CBC
Magnesium Deficiency and Alcoholism

Risks associated with Mg deficiency in alcoholism:
 • Affects protein synthesis. energy production,
aggregation that was normalized ... Alcoholism #alcohol #pathophysiology
Diabetic Myonecrosis (Diabetic Muscle Infarction)
 • Spontaneous ischemic necrosis of skeletal muscle (anterior thigh or calf)
Common pattern: ↑CK ... 6 months - CMC
C.diff - Clostridioides Difficile Infection (CDI) - Diagnosis and Management - GrepMed Handbook

Clinical Presentation + Progression:
Difficile Infection (CDI ... Perforation) Pathophysiology ... x 10d • 1st CDI ... for recurrent CDI ... IDSA 2021 CDI