44 results
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Non-Malignant • Amyloidosis ... • Gaucher's Disease ... Glycogen Storage Disease ... myelofibrosis) Inflammatory ... Algorithm #Causes #Hematology
Amyloidosis - Summary
Group of disorders associated with extracellular deposition of fibrils formed from low-molecular-weight proteins in
(AA) → Chronic Inflammatory ... Clinical suspicion ... the extent of disease ... Clinical Manifestations ... • Circulating inflammatory
Sarcoidosis 
Non-caseating granulomas (Composed of T-helper & inflammatory cells) 
Clinical:
 • Disease fatal in 10% of
of T-helper & inflammatory ... cells) Clinical ... : • Disease fatal ... dysrhythmias • Ophthalmologic
Central Retinal Vein Occlusion (CRVO)
 - Pathophysiology not fully understood; possibly due to thrombus located in
Occlusion (CRVO) - Pathophysiology ... retinal vascular disease ... retinopathy) #Clinical ... #Ophthalmology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Cerebrovascular Disease ... , PRES Pathophysiology ... Treatment: • Inflammatory ... CNS #neurology #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
ANA ≠ Autoimmune Disease ... likely it will be clinically ... Drug-Induced, Inflammatory ... Bowel Disease, ... ANA #patterns #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... (25-75%): Inflammatory ... Behcet syndrome (Clinical ... inhibitors • Uveitis- Ophthalmology ... signs #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... production of pro-inflammatory ... accumulation of clinical ... Assessment • Clinical ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
background of a highly inflammatory ... release of pro-inflammatory ... fever syndromes Clinical ... Fever is the main clinical ... #Rheumatology
Anterior Non-necrotizing Scleritis - Slit Lamp Ocular Examination

This 57 yo WM reported to clinic complaining of
WM reported to clinic ... conditions, so an inflammatory ... Anterior #Scleritis #clinical ... #video #ophthalmology ... #physicalexam #rheumatology