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Extra-articular and Other Conditions Associated with Joint Pain

Eyes
  • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Rheumatic fever • Amyloidosis ... syndrome - SLE Neurologic ... neuropathy - SLE, Amyloidosis ... , Vasculitis (e.g ... Macroglossia - Amyloidosis
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
large vessels - Arteritis ... temporalis (giant-cell arteritis ... - Takayasu arteritis ... - Inflammatory ... syndrome induced by chronic
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis
 • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
Solid tumors: Renal ... Non-infectious Inflammatory ... , Vasculitis (Temporal ... arteritis is prob ... the most common vasculitis
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... - Anti-GBM Disease ... , Behcet's Disease ... , Inflammatory Myositis ... failure - Cancer: Amyloidosis
Intrinsic Renal Disease - Differential Diagnosis
Vascular:
 • Macrovascular: Renal artery occlusion, Fibromuscular disease
 • Microvascular: TTP/HUS,
Intrinsic Renal ... Disease - Differential ... Athero-embolic, HTN, Vasculitis ... FSGS, Diabetic, Amyloidosis ... #Disease #nephrology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
infection • Lyme disease ... Dermatomyositis Erythema chronicum ... Scleroderma • Amyloidosis ... Hypersensitivity vasculitis ... Antiphospholipid-antibody syndrome • Vasculitis
VITAMINS Mnemonic for Acute / Subacute Peripheral Polyneuropathy

Vascular
Inflammatory: Amyloidosis, vasculitis (often more subacute/chronic)
Toxins: Nitrous oxide, chemo,
Polyneuropathy Vascular Inflammatory ... : Amyloidosis, vasculitis ... more subacute/chronic ... Subacute #Acute #Neurology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
pulmonary and renal ... Eosinophilia, asthma, chronic ... and often causes arthritis ... Syndrome: - Ocular inflammatory ... • Urinalysis (Renal
Etiologies of Peripheral Neuropathy
 • Metabolic / Nutritional: DiabetesB12 deficiency, Uremia/ESRD, Hypothyroidism
 • Medication-induced: ART, Antibiotics,
Syphilis, Lyme disease ... , Leprosy • Inflammatory ... Guillain-Barre, Vasculitis ... , Sarcoidosis, Amyloidosis ... diagnosis #causes #neurology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
ANCA-positive vasculitis ... ANCA-negative vasculitis ... IgA-associated vasculitis ... erythematosus, Rheumatoid arthritis ... differential #diagnosis #nephrology