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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Systemic Lupus Erythematosus ... Lupusreference #TMAs ... Systemic #Lupus #Erythematosus ... #SLE #hematology ... differential #diagnosis
Initial triage of the neutropenic adult - Algorithm for the evaluation and treatment of adult patients
the neutropenic adult ... evaluation and treatment ... of adult patients ... Algorithm #workup #diagnosis ... #hematology #biopsy
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Clinical Manifestations ... Systemic Lupus Erythematosus ... Systemic #Lupus #Erythematosus ... Signs #Symptoms #Rheumatology ... #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
arthritis (sJIA) • Adult-onset ... fever syndromes Clinical ... Fever is the main clinical ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential Diagnosis ... Post-op surgery • Trauma ... Non malignant hematologic ... effect following treatment ... #Differential #Diagnosis
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Disease Clinical ... Complications: MAS ... #management #treatment ... #rheumatology
Hypereosinophilia and Hypereosinophilic Syndrome

 • Secondary Hypereosinophilic Syndrome
 • Clinically Relevant HES Variants
 • When to
Hypereosinophilic Syndrome • Clinically ... disorders • Diagnosis ... and Treatment Algorithm ... Syndrome #HES #Hematology ... #eosinophils #diagnosis
Erythematous Rashes - THE ALGORITHMIC APPROACH

Characterized by diffuse redness of the skin due to
capillary congestion, erythematous
Erythematous Rashes ... are present, the diagnosis ... usually to TEN in adults ... the differential diagnosis ... #Diagnosis #Dermatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Systemic Lupus Erythematosus ... (SLE) Clinical ... permeability Diagnosis ... #cerebritis #diagnosis ... #management #treatment
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary
 • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... (SLE) - Diagnosis ... 40, F:M 9:1 • Clinical ... life-threatening • Treatment ... #Summary #rheumatology