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management rheumatology differential cardiology adultonset arthritis hematology hemophagocytic hlh infections lymphohistiocytosis microbiology summary activation bronchiectasis canimorsus capnocytophaga causes erythematosus francisella
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... Disease (AOSD) ... : High spiking fever ... : high fever, CRP ... #Disease #AOSD
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... triad: Fever, Arthralgia ... Complications: MAS ... #Disease #diagnosis ... #management #treatment
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Differential Diagnosis ... leishmaniasis • Adult ... Still's • Gonococcal ... : • Still's disease ... #Differential #Diagnosis
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... #onset #Stills ... #disease #AOSD #
Causes of Fever of Unknown Origin (FUO) - Differential Diagnosis • Infection: Extrapulmonary tuberculosis, Abscess, Endocarditis,
- Differential Diagnosis ... tuberculosis, Abscess, Endocarditis ... , Sarcoidosis, Adult ... onset Still's disease ... #Differential #Diagnosis
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... erythematosus [SLE], AOSD ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
active ROM +/- fever ... , chills, malaise ... osteomyelitis, trauma ... necrosis, Lyme disease ... Treatment: admission
Tularemia - Diagnosis and Management Summary Francisella tularensis - Aerobic fastidious gram-negative Coccobacillus - Zoonotic Infection •
Ulceroglandular: Fever ... More common in adults ... : • Severe Disease ... #management #treatment ... #infectiousdiseases
Endocarditis Summary Who? Infectious: • Pre-existing valvular disease • Prosthetic valve • Congenital heart disease • IV substance use • IV catheter • Recent
Generalized: • Chills ... night sweats, fever ... Paradoxical emboli via ASD ... Diagnosis? ... Persistent bacteremia/fevers
Capnocytophaga Pathogen: Capnocytophaga • 9 species, C. canimorsus responsible for the majority of infections • Gram-negative rod,
• Cellulitis: Fever ... , Chills, General ... 13%), Pneumonia, Endocarditis ... microbiology #zoonotic #infectiousdiseases ... #treatment
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