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management differential rheumatology disease oncology thrombocytosis abdominal activation adultonset apml calcium cancer cardiology causes chf chronic clinical cll cppd criticalcare
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... Algorithm Spurious ... Infectious: • Acute ... Post-op surgery • Trauma ... effect following treatment
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
- Differential Diagnosis ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... infarction, Severe trauma ... #Algorithm #hematology
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm Look for surgical abdomen Upper quadrant: R/O cardiac,
Diffuse Acute Abdominal ... Algorithm Look ... : R/O cardiac, pulmonary ... Musculoskeletal • Trauma ... Irritable bowel syndrome
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Complications: MAS ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... arthritis (sJIA) • Adult-onset ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... Renal Failure Treatment ... #management #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... microglobulin Treatment ... • Richter’s Syndrome ... ’s lymphoma or acute ... workup #oncology #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... also observed in adults ... presents as an acute ... • Bicytopenia Treatment ... #hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular ... vein: Budd-chiari syndrome ... , CMV, VZV • Trauma ... #algorithm #hepatology
Orthopedic Emergencies Compartment Syndrome • An increase in compartment pressure to the point where tissue perfusion is
fractures in young adults ... days after an acute ... • Diagnosis: ... H/O antecedent trauma ... #management #treatment
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