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management hematology oncology rheumatology syndrome algorithm causes symptoms hemophagocytic hlh lymphohistiocytosis neurology thrombocytosis abdominal activation adultonset apml arthritis behcet bronchiectasis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... fraction < 20% Differential ... Complications: MAS ... hepatitis • Pulmonary ... #treatment #rheumatology
Diffuse Acute Abdominal Pain (<72 hours) - Differential Diagnostic Algorithm Look for surgical abdomen Upper quadrant: R/O cardiac,
Diffuse Acute Abdominal ... Pain (<72 hours ... ) - Differential ... : R/O cardiac, pulmonary ... Musculoskeletal • Trauma
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Infectious: • Acute ... disorders • Celiac disease ... Post-op surgery • Trauma ... effect following treatment ... #Causes #Hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... Rebound effect from treatment ... Vasculitides, IBD, Celiac disease ... infarction, Severe trauma
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
- Arthritis Differential ... Diagnosis Framework ... noninflammatory Signs ... Noninflammatory • Trauma ... arthritis • Adult
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
age, however the disease ... also observed in adults ... : HLH signs and ... presents as an acute ... #hematology
Chagas Disease - American Trypanosomiasis - Diagnosis and Management Summary Chagas disease (American trypanosomiasis) is an infectious
Trypanosomiasis - Diagnosis ... weeks incubation Acute ... Romana's sign ... 80%) (abdominal pain ... Tests - check Acute
Facial Swelling - Differential Diagnosis Framework for Facial Edema Infectious: • Dental abscess • Ludwig's angina • Vincent's angina • Cellulitis •
Diagnosis Framework ... polymyositis • Adult-onset ... Still's disease ... Preeclampsia Dermatologic ... Post-radiotherapy states • Acute
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... • Fever is the main ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Multiple Sclerosis - Summary Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... presents in young adults ... Presentation - Young adults ... Sensitivity to pain ... symptoms) • Acute
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