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rheumatology management disease stills adultonset algorithm causes syndrome thrombocytosis activation arthritis behcet bronchiectasis joint macrophage mas monoarthritis monoarticular msk myoclonus
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's ... arthritis and chronic ... synovitis (40%) Treatment ... #rheumatology # ... #treatment
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Diagnosis Algorithm ... : • Acute or Chronic ... Post-op surgery • Trauma ... effect following treatment
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... fraction < 20% Differential ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... Diagnosis Algorithm ... Rebound effect from treatment ... • Infections: Chronic ... infarction, Severe trauma
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
arthritis (sJIA) • Adult-onset ... erythematosus [SLE], AOSD ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... mL Gf consider MAS ... Treatment - Mild ... Stills #disease #AOSD ... #diagnosis #rheumatology
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
parenchyma Diagnosis ... is abnormal in adults ... mycobacteria Treatment ... #differential # ... diagnosis
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Pain - Arthritis Differential ... Diagnosis Framework ... Noninflammatory • Trauma ... arthritis • Adult ... #Diagnosis #MSK
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Epidemiology: • Young adults ... Behcet disease) Differential ... Arthritis, AS Treatment ... Recurrent and chronic ... signs #symptoms #rheumatology
Causes of Myoclonus - Differential Diagnosis LOCALIZATION: • Cortical: Focal/multifocal: Distal UL+ Face, Action/sensitive induced • Sub-Cortical:
Diagnosis LOCALIZATION ... , post stroke, trauma ... • Sub-acute: OMS ... encephalopathies, CJD • Chronic ... hepatic, septic, pulmonary
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