20 results
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... : • Pathophysiology ... TLS #diagnosis #management ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... (MAS) Classified ... Treatment: • Corticosteroids ... #Diagnosis #Management ... #Hematology #Rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology ... Diagnosis: >3 symptoms ... sepsis), PE, DAH, CHF ... APML #diagnosis #management ... #hematology #oncology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
ARDS to explain symptoms ... : 33% • Treatment ... : Age>60, CKD, CHF ... : No • Treatment ... Transfusion #Reactions #hematology
Iron Deficiency in Heart Failure
Pathophysiology:
Chronic heart failure leads to an increase in inflammatory cytokines → Inflammation
Heart Failure Pathophysiology ... functional ID) Treatment ... improvement in symptoms ... iron #deficiency #CHF ... #cardiology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Disease, PRES Pathophysiology ... CNS #neurology #rheumatology ... cerebritis #diagnosis #management ... #treatment
Optic Neuritis - Diagnosis and Management
 • Epidemiology: Female (75%), 18-50 years,
caucasian
 • Symptoms: Moderate visual
Diagnosis and Management ... caucasian • Symptoms ... lesions (b) • CSF ... corticosteroids TREATMENT ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... HLH signs and symptoms ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
meningitis), MCC CNS symptoms ... Arthritis, AS Treatment ... #diagnosis #management ... #signs #symptoms ... #rheumatology #
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
the chest/trunk Symptoms ... mL Gf consider MAS ... Treatment - Mild ... AOSD #diagnosis #rheumatology ... #management