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differential causes management anemia workup bleeding disorders oncology systemic treatment abnormal bruising classification coagulation dermatology elevatedmcv erythematosus fatigue lupus macrocytic
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Algorithm Infectious ... • Thrombus (e.g ... Non-Malignant • Amyloidosis ... Myeloproliferative disorders (eg ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Pre-analytical cause (e.g ... inhibitory drugs (e.g ... specific inhibitor (e.g ... with systemic amyloidosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
to one factor e.g ... inhibitory drugs e.g ... with systemic amyloidosis ... Prolonged #Causes #diagnosis ... #differential #hematology
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Toxic Damage (e.g ... Displacement (e.g ... Non-lmmune: • HELLP Syndrome ... Foreign Surface (e.g ... #Hematology
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
• Provoked (e.g ... screening, CBC, aPTT ... Hypercoagulable #Workup #hematology ... #diagnosis #algorithm ... #hematology #VTE
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... #hematology #pathophysiology ... #hematology #laboratory
Suspected ACS - OMI vs STEMI - Differential Algorithm The name STEMI cognitively inspires EPs to fail
- Differential Algorithm ... segment is the only ECG ... #Differential #Algorithm ... myocardial #infarction #diagnosis ... #coronary #syndrome
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... - Diagnosis and ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... #treatment #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
(usually IgG) (e.g ... (usually IgM) (e.g ... deficiencies (e.g ... Membrane defects (e.g ... #hematology #anemia
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
- Differential Diagnosis ... Algorithm Infection ... Solid Tumour (e.g ... #Algorithm #Causes ... #Hematology
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