59 results
OSA Questionnaire - STOPBANG
#Diagnosis #PrimaryCare #OSA #ObstructiveSleepApnea #Screening #STOPBANG #Questionnaire
OSA Questionnaire ... #PrimaryCare #OSA
Clinical Manifestations of Systemic Lupus Erythematosus (SLE)

#Systemic #Lupus #Erythematosus #SLE #Manifestations #Signs #Symptoms #Rheumatology #Diagnosis
Manifestations of Systemic Lupus ... ) #Systemic #Lupus ... Manifestations #Signs
There are several screening questionnaires for OSA, although the accuracy of many of them is limited.4,6,7,24
questionnaires for OSA ... #PrimaryCare #OSA
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
DM, SSc, PM/SSc OS ... -52 (Ro52), SSA- ... - SSc, PBC/SSc OS ... , PBC/SjS OS ... SLE, SjS, RA, OSs
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 60-70% - Anti-SSA ... Diagnosis and Lupus ... : Drug-induced lupus ... autoantibodies #signs
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... carpal tunnel, OSA
Treatment of Obstructive Sleep Apnea
Positive airway pressure therapy
   → Positive pharyngeal transmural pressure
ideal if severe OSA ... stimulation → Severe OSA
Systemic Lupus Erythematosus: Gastrointestinal Manifestations
 - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Systemic Lupus Erythematosus ... #Systemic #Lupus ... pathophysiology #signs
Autoantibodies in Rheumatology
 • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
Rheumatology • Lupus ... Anti-Smith, Anti-Ro (SSA ... glycoprotein I (ß2GP), Lupus ... Syndrome: Anti-Ro (SSA
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
(Hx of COPD, OSA