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differential ana antibody antinuclear nuclear rheumatology testing workup abnormal algorithm anemia cytoplasmic disorders enzymes heon hypereosinophilia leukemia lfts liver management
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... Toxic injury to BM ... and petechiae Causes ... #Anemia #oncology ... #hematology #diagnosis
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Scl70 (in some cases ... Scl-70 (in some cases ... NXP-2 (MORC3 or MJ ... #differential #diagnosis ... #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... or if a primary hematologic ... When do you do a BM ... #Differential #Diagnosis ... #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... replacing the BM ... replacing the BM-common ... white blood cell aplasia ... #causes #hematology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Scl70 (in some cases ... Scl-70 (in some cases ... NXP-2 (MORC3 or MJ ... #differential #diagnosis ... #rheumatology
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
evaluation of the pattern ... Areas of diagnostic ... aminotransferase; BMI ... Abnormal #Algorithm #Hepatology ... #Differential #Diagnosis
When to look for clonal/neoplastic hypereosinophilia (HEo)? - Exclusion of frequent causes (Drug-induced HEo, helminthiasis, cancer,
Exclusion of frequent causes ... - Myelogram/BM ... hypereosinophilia #HEON #Diagnosis ... #Signs #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
cells - Blood & BM ... • Cytopenia -> BM ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
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