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transaminitis algorithm acute causes enzymes gastroenterology hematology hepatocellular management abnormal acidosis aclf arterial chemistry cholestatic chronic cirrhosis classification comparison dili
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... Differential Diagnosis ... • DILI (Drug-induced ... liver injury) ... Diagnosis #hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... Liver Injury ... Transaminitis #diagnosis ... #differential # ... hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Liver Injury (DILI ... Chronic - ongoing ↑ LFTs ... or symptoms of liver ... #Liver #Injury ... Idiosyncratic #differential
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
of Severe Acute Liver ... obstruction - Drug-Induced ... liver injury ... Acute #Causes #Differential ... #Hepatology #Diagnosis
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... : Liver Injury ... Injury Differential ... #Injury #Differential ... #Diagnosis #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... #Patterns #Liver ... #Injury #hepatology ... #differential # ... diagnosis
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Failure (ACLF) Clinical ... Hepatitis (AAH) Drug-Induced ... Liver Injury (DILI ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... #LFTs #Abnormal ... #Algorithm #Hepatology ... #Differential #
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
glucose by the liver ... contribution of liver ... mellitus/DKA - Liver ... gluconeogenesis Liver ... Injury: • Reduced
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