37 results
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... inhibitor) 2) Osmotic ... diuretics (e.g. ... #pharmacology #nephrology ... #medications #sites
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
Hypernatremia Classification ... - Osmotic diuretic ... , Loop diuretics ... Postobstructive diuresis ... Comparison #Table #Nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... concentrating defect: • Diuretics ... • Osmotic diuresis ... administration #Hypernatremia ... Diagnosis #Causes #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... • Triamterene OSMOTIC ... DIURETICS • Mannitol ... #Medications #Pharmacology ... summary #table #nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Pathophysiology - Diuretic ... Sites of Action Diuretics ... canagliflozin 2) Osmotic ... Pathophysiology #Diuretics ... Sites #Action #nephrology
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
Hyponatremia Correction ... Indications for ... → Osmotic Demyelination ... 3cc/kg/h, loop diuretics ... rate #management #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - ... • Hypovolemic: Diuretics ... , osmotic (solute ... ) diuresis • Euvolemic ... Workup #Algorithm #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Renal losses, Diuretic ... alkalosis, Ketonuria, Osmotic ... diuresis, Cerebral ... Algorithm #Causes #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
the Nephron - Diuretics ... Acetazolamide 2) Osmotic ... Diuretics (e.g. ... Pathophysiology #Nephrology ... #Nephron #Diuretics
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
periodic paralysis Osmotic ... Tolvaptan) • Treatment ... and euvolemic hyponatremia ... #Nephrology #Pharmacology ... #Medications #Table