29 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... canagliflozin 2) Osmotic ... Adenosine #Nephron ... Sites #Action #nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites ... action on the nephron ... inhibitor) 2) Osmotic ... triamterene) #nephron ... #nephrology #medications
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acting on the Nephron ... - Diuretics and ... Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology ... #Nephron #Diuretics
Hypernatremia Classification and Features According to Volume Status
 - Hypervolemic hypernatremia - Cushing's syndrome, Primary hyperaldosteronism,
Hypernatremia Classification ... - Osmotic diuretic ... , Loop diuretics ... Postobstructive diuresis ... Comparison #Table #Nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Causes of Hypernatremia ... concentrating defect: • Diuretics ... • Osmotic diuresis ... administration #Hypernatremia ... Diagnosis #Causes #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
Summary of Diuretic ... • Triamterene OSMOTIC ... DIURETICS • Mannitol ... Tolvaptan #Diuretics ... summary #table #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - ... • Hypovolemic: Diuretics ... , osmotic (solute ... ) diuresis • Euvolemic ... Workup #Algorithm #nephrology
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Causes of Hyponatremia ... Renal losses, Diuretic ... alkalosis, Ketonuria, Osmotic ... diuresis, Cerebral ... Algorithm #Causes #nephrology
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
Hyponatremia Correction ... Overcorrection of Hyponatremia ... → Osmotic Demyelination ... 3cc/kg/h, loop diuretics ... rate #management #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Methazolamide Osmotic ... loss through the nephron ... #Pharmacology #nephrology