29 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... Their Site of Action ... Acetazolamide 2) Osmotic ... Pathophysiology #Nephrology
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Diuretic Sites of Action ... canagliflozin 2) Osmotic ... Diuretics #Sites #Action ... #nephrology #pharmacology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
Diuretics sites of action ... inhibitor) 2) Osmotic ... #pharmacology #nephrology ... medications #sites #action
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
, Mechanism of Action ... • Triamterene OSMOTIC ... summary #table #nephrology
Causes of Hypernatremia - Differential Diagnosis
Inadequate water intake:
 • Lack of access to water
Extrarenal hypotonic fluid
Hypernatremia - Differential ... Diuretics • Osmotic ... Hypernatremia #Differential ... Diagnosis #Causes #nephrology
Causes of Hypernatremia - Differential Diagnosis Algorithm
Hypernatremia - Excess free water loss, Serum Sodium >145 mmol/L
High
Hypernatremia - Differential ... administration • Osmotic ... Hypernatremia #Nephrology ... #Differential #
Causes of Hyponatremia - Differential Diagnosis Algorithm
Hypovolemia, UNa > 20: 
 • Renal losses, Diuretic excess,
Hyponatremia - Differential ... alkalosis, Ketonuria, Osmotic ... #Hyponatremia #Differential ... Algorithm #Causes #nephrology
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
CAR-T therapy • Osmotic ... #KidneyInjury #differential ... diagnosis #algorithm #nephrology
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
Hypernatremia - Differential ... Hypovolemic: Diuretics, osmotic ... Hypernatremia #Differential ... Workup #Algorithm #nephrology
Workup for Hypophosphatemia - Differential Diagnosis Framework
Rule out spurious hypophosphatemia: paraproteinemia, acute leukemia
Measure Urine Fractional Excretion
Hypophosphatemia - Differential ... syndrome, CA Inh., Osmotic ... Hypophosphatemia #Differential ... Workup #phosphate #nephrology