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differential jaundice pediatrics algorithm gastroenterology hepatology neonatal risk stratification bhutani congenital conjugated inherited management neurotoxicity nomogram thresholds anticoagulation bilirubinemia bleeding
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
Non-hemolytic Disorders of Hyperbilirubinemia ... common hereditary hyperbilirubinemia ... • Unconjugated hyperbilirubinemia ... rarely results in kernicterus ... #hepatology #diagnosis
Approach to Neonatal Jaundice Causes of pathologic hyperbilirubinemia can be classified as due to (1) increased bilirubin
of pathologic hyperbilirubinemia ... (1) increased bilirubin ... , (2) impaired bilirubin ... or (3) impaired bilirubin ... #Diagnosis #Peds
Jaundice Differential Diagnosis: A short guide By Dr. Khudhur Mohammed @khudhur_moh #jaundice #gastroenterology #algorithm #differential #diagnosis #hyperbilirubinemia #bilirubin
Jaundice Differential Diagnosis ... #differential #diagnosis ... #hyperbilirubinemia ... #bilirubin
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
Unconjugated hyperbilirubinemia ... • Increased bilirubin ... posthepatitis hyperbilirubinemia ... reactions) Conjugated hyperbilirubinemia ... Classification #diagnosis
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
to Conjugated Hyperbilirubinemia ... - Differential Diagnosis ... #Conjugated #Hyperbilirubinemia ... #direct #bilirubin ... #Differential #Diagnosis
Urine Color - Differential Diagnosis Red Urine: • Medical conditions: bleeding, porphyria, factitious disorder • Meds: rifampin,
- Differential Diagnosis ... Medical conditions: hyperbilirubinemia ... • Meds: rifampin ... Pseudomonas • Meds ... #Differential #Diagnosis
Inherited forms of Hyperbilirubinemia Major pathways involved in bilirubin production, conjugation, and excretion. Notes: Both the UB
Inherited forms of Hyperbilirubinemia ... pathways involved in bilirubin ... transporting unconjugated bilirubin ... Inherited #forms #Hyperbilirubinemia ... hepatology #pediatrics #peds
HAS-BLED Score - Risk of Major Bleeding in 1 Year Characteristics (1 point each) • Hypertension: Baseline
Cirrhosis, or total bilirubin ... Of antiplatelet meds ... anticoagulation #diagnosis
Threshold for Initiating Exchange Transfusion by Risk Stratum. Bhutani et al. Pediatrics. 1999. #Peds #Pediatrics #Diagnosis #Management
#Peds #Pediatrics ... #Diagnosis #Management ... Neonatal #Jaundice #Hyperbilirubinemia
Assess risk for developing subsequent neurotoxicity. This will tell you: a) phototherapy or b) exchange transfusion #Peds #Pediatrics
transfusion #Peds ... #Pediatrics #Diagnosis ... Neonatal #Jaundice #Hyperbilirubinemia
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