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management differential chronic syndrome workup causes cll hemolytic leukemia lymphocytic mds monoclonal myelodysplastic aclf activation acute agglutinin algorithm apml autoimmune
Aplastic Anemia Summary • Definition • Pathophysiology • DDx: AA vs Hypocellular MDS • Expectation •
Aplastic Anemia ... @ZhuoerXie #Aplastic ... #Anemia #diagnosis ... #oncology #hematololgy
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... : 70 years old, ... cytopenias (usually anemia ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... Diagnosis: • Pancytopenia ... Treatment: • Consider ... #Anemia #diagnosis ... #hematology
Warm vs Cold Autoimmune Hemolytic Anemia Warm Autoimmune Hemolytic Anemia: • Mechanism: IgG and Complement-mediated • Etiology:
Warm vs Cold Autoimmune ... Spherocytes • Treatment ... transient hemolysis • Treatment ... BostonChiefs #Warm #Cold ... #hematology #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency Anemia ... (IDA) Tests: ... Iron #Deficiency #Anemia ... #Fe #diagnosis # ... hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... Test: Donath-Landsteiner ... test #cold # ... #hematology #diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Autoimmune: Warm AIHA, Cold ... Defects: Sickle cell anemia ... Laboratory Tests ... #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... practices that could ... K), H. pylori test ... changes), high MCV anemia ... Causes #Workup #hematology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
in those with CLD ... potential for multiple organ ... months without treatment ... Failure #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
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