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diagnosis pathophysiology radiology complications endocrinology malignant signs symptoms benign bonetumor bony clinical features labeled management osteoporosis pharmacology xray aneurysmalbonecyst arthropathy
Malignant Bone Tumors: Pathogenesis of X-ray appearance • Metastatic bone tumors (aka. cancerous cells from systemic
cells activate osteoblasts ... more than osteoclasts ... activate largely osteoclasts ... bone tumor #BoneTumors
Bone resorption and the relationship between osteoblasts and osteoclasts. RANK is expressed on the osteoclasts,
relationship between osteoblasts ... and osteoclasts ... expressed on the osteoclasts ... RANK stimulates osteoclast ... #Osteoclasts #Bone
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
production of osteoblasts ... and GF's -> Osteoblasts ... expression of osteoclasts ... -> Incr Osteoclasts
Representative X-ray appearance of a primary malignant bone tumor - Ewings Sarcoma • "Interrupted periosteal reaction
LegXRay #Malignant #BoneTumor
Osteosarcoma Most common primary malignant bone tumor in children Most Common Sites of Involvement: 1. Distal femur
Peds #Pediatrics #BonyTumor
Representative X-ray appearance of a primary benign bone tumor - Aneurysmal Bone Cyst • Soft
Labeled #Benign #BoneTumor
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
IGFIR activates osteoblasts
Bisphosphonates for Osteoporosis Treatment or Prevention Bisphosphonates are common medications used in the treatment and prevention
Bisphosophonates inhibit osteoclasts
Fracture Healing (and disruptors of this process) Inflammatory Stage (0-7d) • Fracture disrupts local blood vessels ->
cartilaginous matrix by osteoblasts ... mos - yrs) • Osteoclast-osteoblast ... gentamycin - Toxic to osteoblasts
Malignant Bone Tumors: Clinical Findings and Complications #Malignant #BoneTumors #Bony #Complications #pathophysiology
#Malignant #BoneTumors
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